Saturday, 1 March 2014

Surat Mohon Cuti Raya Haji dan penangguhan hari

Dr. HANITA BT OTHMAN,
Ketua
Jabatan Perkhidmatan Makmal Diagnostik,
Pusat Perubatan Universiti Kebangsaan Malaysia.
 


GOH EU WEI,
Ketua Pelajar ,
Sains Bioperubatan Tahun 3,
Universiti Kebangsaaan Malaysia                                                                                        2 Oktober 2013
                                                                                              
Puan,

PERMOHONAN CUTI RAYA HAJI SELAMA SEHARI

Merujuk kepada perkara diatas, Saya  Goh Eu Wei/Mo.Matrik (IC no.),mewakili pelajar Sains Bioperubatan Tahun 3 Universiti Kebangsaan Malaysia (UKM)  untuk memohon cuti selama sehari, iaitu pada 14 Oktober 2013 bersamaan hari Isnin sehari sebelum Raya Haji yang akan bertarikh 15 Oktober 2013.

2.   Tujuan kami  memohon cuti pada hari Isnin tersebut kerana ingin memberi peluang kepada pelajar yang beragama Islam untuk pulang ke kampung terutama yang tinggal berjauhan untuk menyambut Hari Raya Haji. Sehubungan itu, kami memohon cuti sehari dan ditangguhkan Kursus Diagnosis di Pusat Perubatan Universiti Kebangsaan Malaysia (PPUKM) yang bertarikh pada 14 Oktober 2013.

3.  Dengan ini saya lampirkan senarai nama pelajar yang memohon cuti pada hari tersebut. (LAMPIRAN 1)

4. Sehubungan dengan itu, saya berharap agar pihak puan dapat mempertimbangkan dan meluluskan permohonan cuti tersebut.


Sekian, terima kasih.


Yang benar,

 


(GOH EU WEI)
Ketua Pelajar ,
Sains Bioperubatan Tahun 3,

Universiti Kebangsaaan Malaysia              

MECHANISM OF TOXICITY

The fate of / how it move in body we called them as kinetics. In order for the drugs to enter the body is the one that we don't want. We want them to being excrete out from the body. We want the drug to be in the body in order for it to have some pharmacological responses. At the same we want it to be excreted and eliminated out. Remember, we do not want to have continues effects because drugs is not a magic bullet , it also have side effects. Thus we want to eliminate it out immediately. 

Problems with toxic material, we cannot controlled it. You going to be exposed to the environmental pollutant,you will be consumes food preservatives and additives all the time. At higher level quantity, it can be toxic when it accumulated. We do not want it to be accumulate in our body and we want it to be eliminated out.

So, how a toxic material can go in and can go out is what we learned in Mechanism Of Toxicity. In a dynamicity, is when it go into our body and it lead to adverse effect. It happen when it produce mutations. We do not want mutations - then we will become X-men. What we want is the mutation can be repaired. 

When you're talking about the movement of the toxic in body - it have 4 phases. (ADME) Absorption, Distribution, Metabolism and Excretion. Since it go into the circulatory system, it can go into the liver, brain and other organs. Hence, you can get toxic effect elsewhere because there is distributions. You do not want this to happen in your body. Thus you want the metabolism and excretion to occur immediately. The metabolism and excretion will help the toxicant to be eliminated out. This is by making it more stables and more water soluble, go to kidneys, eliminated it out immediately. Thus, the toxicant do not accumulate in the body to give toxic effects.

In general, in Absorption and Distributions, the factors involved
- size - large size is hard go through absorption, hard to be distributed. Why?  Because to go through the lipid bilayer of the plasma membrane. Talk about lipid bilayer, other factors involved - solubility
- Solubility - we do not want our toxicants to be lipid-soluble. Since our plasma membrane is lipid bilayer, we do not want toxicant s to be lipid soluble. Because it will make them easily to be absorbed and distributed. Unfortunately, 90% of environmental pollutant are very lipid soluble. Since we always exposed to environmental pollutant, we  need to take care of our body.

General characteristics/movements of toxicants in our body.

When we have xenobiotics - foreign compound, that our body did not recognized - and lipid soluble, it will be absorbed easily. Then, it gets into systemic circulation under our skins. And, when you consume xenobiotics, it also can get into systemic circulation because in our GIT have highly perfused with blood vessels because body want to absorb nutrition, vitamins etc. Then, the toxicant will be distributed in body elsewhere. Since your body loves you, loves you, over. Thus, your body don't like everything that get into your body that can give harmful effects. Then body will excrete it through the liver and kidney.

But, its not will be easy as that. Because things that easily be absorbed, it will hard to excreted out since it is very lipid soluble, it will be distributed in body elsewhere even go through your blood brain barrier, even your nerves. So, its hard to be excreted out. Thus, never ever ever try to take heroins, because it is very lipid soluble, it stuck in your brain, no turning back, no U turn and no roundabouts. That's why its hard to treat heroin addicts.

It have to do with distributions. It is difficult to metabolize all the very lipid soluble compound to be excreted. Thus body will send them into the liver to metabolize the toxicant to become more water soluble compound so that it can easily distributed to the kidney and excreted out from it in urine. If you inhaled vaporize materials, you will exhaled it fast and easily. Because it size are small. But, things that have large size will be send to the liver, and other organs that can do metabolism, but liver is the major one.

When we talk about metabolism also not easy as we said. Things that easily go into liver also easy to be metabolized. Not all enzymes can would recognize xenobiotic. Enzymes activity must need lock-and-key fit, So, when xenobiotic go into, how can lock-and-key fit to be occurred. Hard to metabolize. Thus body will cater the foreign compound. Hence, there will be Phase 1 and Phase 2 metabolizing enzymes.

Phase 1 is when to make the xenobiotic recognized by the body. Phase 2 is when conjugation reaction occurs. This happen by attached the lipid soluble compound with very water soluble compound. The compound then will become water soluble compounds. Thus, will easily be excreted out.

Phase 1 = metabolic activation
Phase 2 = detoxification

But, when you metabolic activating the compounds - it also can become harmful.Why? Because before conjugation occurs, the products that have been formed is very active compound. If there is no conjugation that occurs, it can attack our cells. Attack our protein, attack our DNA. Abnormality can happens. That's why good and healthy diet is very important because from that we can get the conjugater for the active compounds. 

We want detoxification more than the metabolic activation. Unhealthy lifestyle will increase you metabolic activation thus increase active compounds in the body. This will then be distributed and will attack micromolecule such as DNA, cells, lipid or proteins. This can lead to abnormality to the cells and become cancer. 


INTRODUCTION TO TOXICOLOGY

When you see a symbol of Skull and Bone logo, what can you actually think from it? Straight away come from your mind?

-err, your boyfriend..? ahaks, just kidding
- Death
-Harmful effect
-Hazardous
-Cautions
-Poison

Basically, when you see it, you know it is a bad thing, that can give a harmful effect. That's why you need precautions in handling it. If you not, you will get death and harmful effect. Thus, toxicology is the study to do that have to do with harmful effect. Its associated with Pharmacology. Logia = study, Pharmaco = Drugs. Drugs is not a a magic bullet, which means it have a side effect that you do not want. Thus, toxicology is a continuous from Pharmacology. 


Arsenic = something good, or something bad? Its a heavy metal. Its a poison. It is a notorious that have been used from along time and STILL have been used especially in murder cases, killing people politician etc. But, arsenic formerly used as a cosmetic ingredient. Because people look at the benefit of arsenic, that can give them look white, smooth and polished their face, but, at the end of the day, its very harmful. They don't know.

Heroin = is a drug, group Morphine. A painkiller. To release cough. Of course their cough being suppressed but they will become addicted to it. Because heroin very lipid soluble. People that start with heroin there will be no turning back. They can never come back to their origin. No roundabout. No U turn even, roundabout no. You stuck there. That's why its very difficult to treat heroin addicts.

Cocaine = you used to put on the head to treat dandruff. Yes, there will be no dandruff, but it will go into your head and then you will become addicts to it. Many celebrities death case due to cocaine addicts. Amy Whitehouse is one of them. Not just she take heroin, she also take cocaine. Those people take cocaine for recreational used but when they take other things, they always end up with death.

What I'm trying to said here, with Skull and Bone, it something adverse, something toxic. They can be used as drugs, they have medicinal benefits, but more importantly if people do not know their adverse effect, people do not know reason of their toxicity, it will become more severe. Very Potent!

So, Toxicology have been start from the old times. Old people do research about it. The first documentation about poison, is when people wrote on a Pirates, paper made from straw, they wrote, all poison. documented all are poison. More importantly it have to do with one person that has widely-used many toxic;
Cleopatra, always people relate her with beauty, as a woman, she's the prettiest, but, deep down inside, she is very evil,  because she only seen beautiful people only. Beauty is not important, but inside is very important. But, she was very evil. Why? Because she was a toxicologist. You see, a lot of poison to kill people, to gain power and to rule the land. Cleopatra is the last Pharaoh. She is the only female Pharaoh. That's why, to rule the lands, to gain power, she had using a lot of toxic material, poison. That's why she is considered a very good toxicologist. Even during her death. Her death is like a ritual. In history, during her death, what she did, she put a desert snake on her chest, the snake pecked her, then she died. But, that's history. In 2011, there was a research on toxicology that associated with history, They said Cleopatra did not died because of the snake venom, what she did was actually, since she is a good toxicologist, she already concocted, she already drink the mixture of poison to died. She put the snake on her chest only just as a ritual. What actually that lead to her death is due to that poison, not due to the venom of the snake. That's why Toxicology is important. 
Then you have in 17000 also, this person Catherine De Medici, this Italian women married to the French King and become a French queen. Thus, people do not like her. Thus, when she become a queen, become an Italian, she want a power. Its about power and about politics. When you read about sleeping beauty, snow white, you have the evil step-mother, evil queen, she was based for that character, because she was also a good toxicologist. What she did was, if you heard about the snow white, she give an apple, that what Catherine did also. She had that apple, she put vapor of cyanide into the apple, people eat and they all died. She was the one who make the apple. She actually the evil. She also learn about the toxicology, she was very good in mixing of poison. Why? To get into a French loyalty is very hard and the same time for the 1st ten years she did not have children to continued the power. But after 10 years she did have children. I don't know how, but she was a good toxicologist. She have 10 children. But, 2 of the last girls died because they not safe in her womb. She broke off their feet. If you read about her history, you see that she is very cruel and evil. Then she had 3 first son, and all of them capable to become a king in France on three consecutive sections. Although all her children all in 40 of age, 10 of age can become a king, but, they all are very weak and sickly, people did not like it, because the successor unable to defend their county. But, she managed to make her three son become a king. Why? Because she was a good toxicologist, when people have bad hidden agenda, hidden conspiracy, she killed all them. That's why, she is very evil. And if now, if you want to see the luxury and go to France, try to visit De Chateau where you will see 200 hundred cabinets which look like a wall, that contains full of her poison collection. She is a very good scientist She very interested in science, astronaut, and all chemical. She made all of this poison. To get into this rooms of the De Chateau, is like when you read Elizabeth story, when you see a door that can be pushed but it bring you into another rooms. It's ;like that. She made that to concurred all of her mixed poison herself.

More importantly is about a man, Sir Percivall Pott, this one not a bad guy. She made a research on chimney sweepers. These people go from house to another house to clean the trapped soot in the chimney. Usually chimney sweepers is a group of people of small children, thinner people and poor people. Thin and smaller people easily can go into the chimney to do this job. Sir Percivall Pott, the first person do research and linked epidemiology with toxicity by relate chimney people with scrotal cancer. Because most of chimney people are men. And what you will see how they can get scrotal cancer. Why not lung cancer? Why not dermal cancer while it is the site where exposed to chimney material more. Chimney material are very toxic, you have tar, soot, polyaromatic hydrocarbon that all are very carcinogenic. Why not they got lung cancer since they breath in the chimney? Why not skin cancer? How come they can get scrotum cancer? Chimney people look black people because they have black skin, but they actually are white people! Shock are we? But, think, why scrotal cancer?? Take that as your homework, put that in your head.

What is very important here also, is that what had happen in 17000 also still happen now. And, I'm not talking about Western people, I'm talking about our local people, our local farmers, I'm talking about person who his work is spray pesticides. What have we done and research, people who exposed to pesticides, pesticides sprayer also develop scrotal cancer. So, think. Why all of these people, chimney sweeper, exposed to pesticide sprayer get scrotal or reproductive cancer?  It's not happen just in 17000 only, its also happen now. That why we have group community research, we go to see farmers, tell them and educated them how to use pesticides cautiously . Even in our own backyard, its quit rampant. Means, there is increasing in scrotal cancer. 

Then you have Minamata Disease, in Japan. Where the mother have an adult son, did not have legs, hands and it is very painful. What happen was, in Minamata Bay there is a factory that throw out Mercury. What happen was, the mercury go into the sea, go into the Minamata Bay, people there eat seafood, fish etc that have contaminated with mercury. Its get into the mother. The mercury poisons give effect more to the fetus/the baby than the mother/not the adult people. Why? Think.

The Mother of Environment Movement, Racheal Carson, that wrote on Silent Spring (1962). When you have 4 seasons, spring season should be like birds chirping, flowers blooming, animals err chase each other. But what happen was in her place, during that time, the spring become silence. Then she realized when her childhood day, all the birds chirping, there are beetles sounds etc. But then, all lost. Everything become silence. The spring become silence. This because there is starting in uses of a pesticides to kill insects and to controlled the agriculture products, its not just they can controlled them, but, at the same time all the ecosystem and environmental become exposed to the pesticides which leads to silence spring. Then she wrote the book, and only with that book that lead to released of legislative act, registration, all sorts of controls on pesticides to be used. That why she become The Mother of Environment. 

Tokyo Subway Attack (1995), a bomb is detonated by a man in a subway underground, which there have a lot of people. Bomb explode which lead to gas off into the air and killed all the people in the subway. What have he used is the organophosphate, a sarin, the chemical warfare. He used sarin, people become breathless thus killed them. Whats more severe, its happen now, in Syria war - civil war. What they did was, they used the chemical warfare which is Sarin, to kill the civilian, not the soldier, but the children and women. But largely the children. Because they did not want and allow the children to grow to become vengeance. Thus, they killed the children. This is very illegal in any war! When you have a war, there is some rules and legislation. You cannot disturbed the civilian. Soldier fight with soldier only. What happen in Syria is the opposites. But, we will see. God is Great.

So, toxicology - generally from the old times until now is very important. you need to know not because you want to kill people but you need to know what its effect and how it kill people, how its handling and manage them. At the same time is there any treatment to the adverse effects.

What is you understood about the poison? Its bad, its symbol is Bone and Skull - not means if you eat them you can become slim - Its shows you the adverse effect. So, expand your knowledge with this questions. 

If you see there is a glass of arsenic and a glass of plain water in a laboratory. Directly what would you do?

-separated them. Separated them and put your book in the middle and study. Is that good? No. Why? because you friends can be exposed to them. If being exposed to water maybe nothing, but exposed to arsenic - you dont want. Meaning here what? Means, comparing arsenic than water, arsenic is poison and toxic. 

Firstly in the lab, you can identified them as toxic or not.  Toxic compound we defined them as hazardous. Hazard compound is their potential to become harm is there already. Its can give harm even though you take just a glass of arsenic. 

Then you separated them - toxic and not toxic one. Keep them. How to keep them if it in a glass? Keep it in a proper cabinet with cautiously. Why, because they are Skull and Bone. To manage them, put on label,  then keep it lock in a cabinet. Because its very toxic.

So, its very clearly that arsenic is very poison. So, thus this means water is not toxic? Yeah, if its being contaminated. But, if the water in a bottle? Is the water can be toxic or harmful? Yes. How? Think.

The water can become toxic when you take it a lot! Right? You can die when you consume water in a large quantity. Have you heard there are people who die because water intoxication? One case, in America, there is Hold You Wee to Play Win a Wii Competitions. A women, take water, play, and hold still her wee. Come back home, she died. Postmortem show she died because she holding her wee. In 2011, a man died because water overdose. This man take ecstasy - make you euphoria. He is an ecstasy user. He go to clubs, with techno sound - which very good to ecstasy people. It make them more passionate to dancing. They become high. At the same time, when you are so high you body become lethargy. And died because you did not rest. In this case, this man know the culture in taking ecstasy. Many ecstasy people died because dehydration. Lethargy - not take water - dehydration - then died. This man knows it and he keep on takinh water more and more to avoid dehydration. But then died due to water intoxication.

Meaning here, arsenic is toxic, water also CAN BE toxic. The father of toxicology; Paracelsus said that "Everything is Toxic" What difference between toxic and remedy is the dose.


Saturday, 27 April 2013

Contoh Teks UcapaN Pengetua Pertandingan Badminton


Assalamulaikum wbt dan salam perpaduan,
Y.Bhg. Dr Mohd Sham Bin Othman,
Timbalan Pengetua 1,
Kolej Tun Syed Nasir,
Y.Bhg. Cik Umi Izzati Bt Sedon
Felo Pemantau Jaksa Sukan & Rekreasi
Kolej Tun Syed Nasir,
Ahli-ahli organisasi Kelab Badminton,
Serta para peserta yang kasihi sekalian.
Terlebih dahulu marilah kita memanjatkan kesyukuran ke hadrat Allah SWT kerana  dengan limpah kurniaNya dapat kita bersama-sama berkumpul dalam majlis yang penuh bersejarah dan amat bermakna ini.
Sesungguhnya Pertandingan Badminton Piala Emas KTSN 2013 ini merupakan salah satu aktiviti kelab yang dianjurkan oleh Kelab Badminton KTSN pada setiap tahun.
Pertandingan ini bertujuan untuk membina sahsiah, semangat berpasukan dan muhibbah dalam kalangan pelajar KTSN. Hal ini berlaku apabila setiap peserta mewakili setiap course/program masing-masing contohnya Fakulti Farmasi, Fakulti Perubatan, dan Sains Kesihatan seperti Biomed, EVH, Optometri dan lain-lain yang terlibat. Semua peserta telah bermain bersungguh-sungguh mencapai kemenangan untuk menaikkan nama fakulti atau program masing-masing.
Bersukan seperti badminton ini juga berperanan sebagai alat perpaduan tanpa mengira ideology. Penyertaan aktiviti sukan tidak terhad kepada kaum tertentu dan seperti yang anda lihat terdapat para peserta kita yang terdiri daripada kalangan kaum Melayu, Cina dan India. Saya dapat lihat juga terdapat gabungan antara mereka ketika bertanding. Saya berasa berbangga dengan pencapaian yang telah ditonjolkan oleh mahasiswa-mahasiswa KTSN ini. Tahniah saya ucapkan.
Selain itu, pertandingan ini dapat mengalakkan persaingan yang sihat ke arah membentuk kecermerlangan sukan di KTSN. Untuk pengetahuan semua, misi bagi pertandingan ini juga adalah untuk menarik minat semua lapisan mahasiswa dan mahasiswi agar mereka yang terlibat ini dapat menajamkan dan mengeluarkan bakat yang terpendam dan seterusnya dapat mewakili kolej ke peringkat yang lebih tinggi seperti SUKEM dan SUKIPT. Di samping itu, para pelajar yang masih baru dapat mendalami sukan badminton lantas memilih sukan badminton sebagai sukan kegemaran dan dijadikan hobi di masa kelapangan.
Amalan gaya hidup yang sihat perlu dipupuk dengan mengimbangkan antara akademik dan kokurikulum. Bermain badminton atau apa sahaja sukan boleh menyihatkan tubuh badan.  Ada perpatah Arab yang berbunyi  `Akal yang sihat adalah dari badan yang sihat’..memang benar.. Bila kita bersukan , badan akan terasa segar dan menjadi lebih bertenaga kerana lemak yang terbakar tadi ditukarkan kepada sumber tenaga anda.  Pada masa yang sama akal kita akan dapat beroperasi dengan baik..ini insyaALLAH akan dapat menambahkan lagi kekusyukkan kita ketika belajar, bersolat dan lain-lain..dan jika sukan yang dimainkan adalah badminton, maka secara tidak langsung akan menguatkan tangan kita apabila kita menghayunkan raket badminton ke kiri dan ke kanan. Bukan tangan dahaja, malah kaki juga bergerak pada masa yang sama seperti berlari dan melompat untuk mengejar shuttle.
Sukan seperti badminton memberi banyak faedah kepada kesihatan kita dan juga salah satu cara untuk awet muda dengan meningkatkan kadar HDL kolestrol baik dan mengurangkan kadar kolestrol yang puaka dalam tubuh. Maka, ia amat bagus untuk jantung dan membantu mengawal tekanan darah tinggi.
Semua kebaikan yang disebut tadi akan membuatkan anda rasa kuat, sihat, bermotivasi, bersemangat dan muda!
Maka, saya menggalakkan para pelajar semua menyertai apa sahaja aktiviti dan program yang dianjurkan oleh pihak kolej samada program yang berbentuk kurikulum mahupun kokurikulum. Dan kita jangan berputus asa sekiranya anda gagal dalam pertandingan dan acara yang dipertandingkan kerana adat perlawanan ada kalah dan ada pemenangnya. Mungkin pada tahun ini anda kalah, tetapi yakin dan percayalah pada tahun hadapan sekiranya anda berusaha dengan lebih gigih lagi insyAllah anda pula yangakan menang dan berjaya.
Hadirin dan hadirat sekalian,
Saya rasa tidak perlu berucap terlalu panjang kerana kita ada agenda seterusnya iaitu penyampaian hadiah kepada para pemenang, maka dengan lafaz Bismillah hirrahmanirrahim saya dengan ini merasmikan penutupan Pertandingan Badminton Piala Emas KTSN 2013. Sekian sahaja ucapan saya pada kali ini. Wabillahi taufiq wal hidayah wa salamu ‘alaikum.

Sunday, 21 April 2013

What is the meaning of "FRIEND"??

One of my colleagues make a video and ask everyone, one by one; "What if the meaning of FRIEND?"

She ask me, I'm speechless.. Not just me, but almost everyone like that.. So, if I ask you; "What is FRIEND?" What will be your answer?

To me, friend is a term that can't be described in just a few words.. The exact meaning of it, nobody knows..

Its depends on each individual itself to describe what is friend to them..

For me, FRIEND is

someone who I can laugh together,

make jokes together,

somebody who I care most of,

although not always meet together but there is inside feeling where we always miss each other,

when together we become crazy people

,laugh hard not care about others,

cry together when it sad,

tell bad jokes to them, but nobody of us cares



I just pick this from other blogs:

AM NOT YOUR FRIEND IF.....
you have to think before you speak to me!

I AM NOT YOUR FRIEND IF.....
my presence ever makes you feel uncomfortable!

I AM NOT YOUR FRIEND IF.....
you have to thank me for everything i do for you!

I AM NOT YOUR FRIEND IF.....
you have to say sorry for everything
that you don't do!

I AM NOT YOUR FRIEND IF.....
you have to ask me for favors!

I AM NOT YOUR FRIEND IF.....
you think i would not be curious to
know your new philosophy of life!

I AM NOT YOUR FRIEND IF.....
you go by what i say and do not understand
what i don't say!

I AM NOT YOUR FRIEND IF.....
you think that listening to your dreams
would put me to sleep!

I AM NOT YOUR FRIEND IF.....
you think that seeing you in pain, would
not bring a tear to me!

I AM NOT YOUR FRIEND IF.....
you think I do not remember the first time
we met!

I AM NOT YOUR FRIEND IF.....
you don't see the thousand ways I try to
make you happy!

Thursday, 21 June 2012

Demi dia

Sesiapa pun yang engkau pilih, pastikan pasanganmu itu, kau bawanya ke syurga.. Bukan untuk dunia semata-mata. Lebih baik sekiranya kedua-dua berniat untuk menuju ke jalan-Nya. Bukan apa, tetapi demi mendapat keREDHAANnya..