Saturday 1 March 2014

INTRODUCTION TO TOXICOLOGY

When you see a symbol of Skull and Bone logo, what can you actually think from it? Straight away come from your mind?

-err, your boyfriend..? ahaks, just kidding
- Death
-Harmful effect
-Hazardous
-Cautions
-Poison

Basically, when you see it, you know it is a bad thing, that can give a harmful effect. That's why you need precautions in handling it. If you not, you will get death and harmful effect. Thus, toxicology is the study to do that have to do with harmful effect. Its associated with Pharmacology. Logia = study, Pharmaco = Drugs. Drugs is not a a magic bullet, which means it have a side effect that you do not want. Thus, toxicology is a continuous from Pharmacology. 


Arsenic = something good, or something bad? Its a heavy metal. Its a poison. It is a notorious that have been used from along time and STILL have been used especially in murder cases, killing people politician etc. But, arsenic formerly used as a cosmetic ingredient. Because people look at the benefit of arsenic, that can give them look white, smooth and polished their face, but, at the end of the day, its very harmful. They don't know.

Heroin = is a drug, group Morphine. A painkiller. To release cough. Of course their cough being suppressed but they will become addicted to it. Because heroin very lipid soluble. People that start with heroin there will be no turning back. They can never come back to their origin. No roundabout. No U turn even, roundabout no. You stuck there. That's why its very difficult to treat heroin addicts.

Cocaine = you used to put on the head to treat dandruff. Yes, there will be no dandruff, but it will go into your head and then you will become addicts to it. Many celebrities death case due to cocaine addicts. Amy Whitehouse is one of them. Not just she take heroin, she also take cocaine. Those people take cocaine for recreational used but when they take other things, they always end up with death.

What I'm trying to said here, with Skull and Bone, it something adverse, something toxic. They can be used as drugs, they have medicinal benefits, but more importantly if people do not know their adverse effect, people do not know reason of their toxicity, it will become more severe. Very Potent!

So, Toxicology have been start from the old times. Old people do research about it. The first documentation about poison, is when people wrote on a Pirates, paper made from straw, they wrote, all poison. documented all are poison. More importantly it have to do with one person that has widely-used many toxic;
Cleopatra, always people relate her with beauty, as a woman, she's the prettiest, but, deep down inside, she is very evil,  because she only seen beautiful people only. Beauty is not important, but inside is very important. But, she was very evil. Why? Because she was a toxicologist. You see, a lot of poison to kill people, to gain power and to rule the land. Cleopatra is the last Pharaoh. She is the only female Pharaoh. That's why, to rule the lands, to gain power, she had using a lot of toxic material, poison. That's why she is considered a very good toxicologist. Even during her death. Her death is like a ritual. In history, during her death, what she did, she put a desert snake on her chest, the snake pecked her, then she died. But, that's history. In 2011, there was a research on toxicology that associated with history, They said Cleopatra did not died because of the snake venom, what she did was actually, since she is a good toxicologist, she already concocted, she already drink the mixture of poison to died. She put the snake on her chest only just as a ritual. What actually that lead to her death is due to that poison, not due to the venom of the snake. That's why Toxicology is important. 
Then you have in 17000 also, this person Catherine De Medici, this Italian women married to the French King and become a French queen. Thus, people do not like her. Thus, when she become a queen, become an Italian, she want a power. Its about power and about politics. When you read about sleeping beauty, snow white, you have the evil step-mother, evil queen, she was based for that character, because she was also a good toxicologist. What she did was, if you heard about the snow white, she give an apple, that what Catherine did also. She had that apple, she put vapor of cyanide into the apple, people eat and they all died. She was the one who make the apple. She actually the evil. She also learn about the toxicology, she was very good in mixing of poison. Why? To get into a French loyalty is very hard and the same time for the 1st ten years she did not have children to continued the power. But after 10 years she did have children. I don't know how, but she was a good toxicologist. She have 10 children. But, 2 of the last girls died because they not safe in her womb. She broke off their feet. If you read about her history, you see that she is very cruel and evil. Then she had 3 first son, and all of them capable to become a king in France on three consecutive sections. Although all her children all in 40 of age, 10 of age can become a king, but, they all are very weak and sickly, people did not like it, because the successor unable to defend their county. But, she managed to make her three son become a king. Why? Because she was a good toxicologist, when people have bad hidden agenda, hidden conspiracy, she killed all them. That's why, she is very evil. And if now, if you want to see the luxury and go to France, try to visit De Chateau where you will see 200 hundred cabinets which look like a wall, that contains full of her poison collection. She is a very good scientist She very interested in science, astronaut, and all chemical. She made all of this poison. To get into this rooms of the De Chateau, is like when you read Elizabeth story, when you see a door that can be pushed but it bring you into another rooms. It's ;like that. She made that to concurred all of her mixed poison herself.

More importantly is about a man, Sir Percivall Pott, this one not a bad guy. She made a research on chimney sweepers. These people go from house to another house to clean the trapped soot in the chimney. Usually chimney sweepers is a group of people of small children, thinner people and poor people. Thin and smaller people easily can go into the chimney to do this job. Sir Percivall Pott, the first person do research and linked epidemiology with toxicity by relate chimney people with scrotal cancer. Because most of chimney people are men. And what you will see how they can get scrotal cancer. Why not lung cancer? Why not dermal cancer while it is the site where exposed to chimney material more. Chimney material are very toxic, you have tar, soot, polyaromatic hydrocarbon that all are very carcinogenic. Why not they got lung cancer since they breath in the chimney? Why not skin cancer? How come they can get scrotum cancer? Chimney people look black people because they have black skin, but they actually are white people! Shock are we? But, think, why scrotal cancer?? Take that as your homework, put that in your head.

What is very important here also, is that what had happen in 17000 also still happen now. And, I'm not talking about Western people, I'm talking about our local people, our local farmers, I'm talking about person who his work is spray pesticides. What have we done and research, people who exposed to pesticides, pesticides sprayer also develop scrotal cancer. So, think. Why all of these people, chimney sweeper, exposed to pesticide sprayer get scrotal or reproductive cancer?  It's not happen just in 17000 only, its also happen now. That why we have group community research, we go to see farmers, tell them and educated them how to use pesticides cautiously . Even in our own backyard, its quit rampant. Means, there is increasing in scrotal cancer. 

Then you have Minamata Disease, in Japan. Where the mother have an adult son, did not have legs, hands and it is very painful. What happen was, in Minamata Bay there is a factory that throw out Mercury. What happen was, the mercury go into the sea, go into the Minamata Bay, people there eat seafood, fish etc that have contaminated with mercury. Its get into the mother. The mercury poisons give effect more to the fetus/the baby than the mother/not the adult people. Why? Think.

The Mother of Environment Movement, Racheal Carson, that wrote on Silent Spring (1962). When you have 4 seasons, spring season should be like birds chirping, flowers blooming, animals err chase each other. But what happen was in her place, during that time, the spring become silence. Then she realized when her childhood day, all the birds chirping, there are beetles sounds etc. But then, all lost. Everything become silence. The spring become silence. This because there is starting in uses of a pesticides to kill insects and to controlled the agriculture products, its not just they can controlled them, but, at the same time all the ecosystem and environmental become exposed to the pesticides which leads to silence spring. Then she wrote the book, and only with that book that lead to released of legislative act, registration, all sorts of controls on pesticides to be used. That why she become The Mother of Environment. 

Tokyo Subway Attack (1995), a bomb is detonated by a man in a subway underground, which there have a lot of people. Bomb explode which lead to gas off into the air and killed all the people in the subway. What have he used is the organophosphate, a sarin, the chemical warfare. He used sarin, people become breathless thus killed them. Whats more severe, its happen now, in Syria war - civil war. What they did was, they used the chemical warfare which is Sarin, to kill the civilian, not the soldier, but the children and women. But largely the children. Because they did not want and allow the children to grow to become vengeance. Thus, they killed the children. This is very illegal in any war! When you have a war, there is some rules and legislation. You cannot disturbed the civilian. Soldier fight with soldier only. What happen in Syria is the opposites. But, we will see. God is Great.

So, toxicology - generally from the old times until now is very important. you need to know not because you want to kill people but you need to know what its effect and how it kill people, how its handling and manage them. At the same time is there any treatment to the adverse effects.

What is you understood about the poison? Its bad, its symbol is Bone and Skull - not means if you eat them you can become slim - Its shows you the adverse effect. So, expand your knowledge with this questions. 

If you see there is a glass of arsenic and a glass of plain water in a laboratory. Directly what would you do?

-separated them. Separated them and put your book in the middle and study. Is that good? No. Why? because you friends can be exposed to them. If being exposed to water maybe nothing, but exposed to arsenic - you dont want. Meaning here what? Means, comparing arsenic than water, arsenic is poison and toxic. 

Firstly in the lab, you can identified them as toxic or not.  Toxic compound we defined them as hazardous. Hazard compound is their potential to become harm is there already. Its can give harm even though you take just a glass of arsenic. 

Then you separated them - toxic and not toxic one. Keep them. How to keep them if it in a glass? Keep it in a proper cabinet with cautiously. Why, because they are Skull and Bone. To manage them, put on label,  then keep it lock in a cabinet. Because its very toxic.

So, its very clearly that arsenic is very poison. So, thus this means water is not toxic? Yeah, if its being contaminated. But, if the water in a bottle? Is the water can be toxic or harmful? Yes. How? Think.

The water can become toxic when you take it a lot! Right? You can die when you consume water in a large quantity. Have you heard there are people who die because water intoxication? One case, in America, there is Hold You Wee to Play Win a Wii Competitions. A women, take water, play, and hold still her wee. Come back home, she died. Postmortem show she died because she holding her wee. In 2011, a man died because water overdose. This man take ecstasy - make you euphoria. He is an ecstasy user. He go to clubs, with techno sound - which very good to ecstasy people. It make them more passionate to dancing. They become high. At the same time, when you are so high you body become lethargy. And died because you did not rest. In this case, this man know the culture in taking ecstasy. Many ecstasy people died because dehydration. Lethargy - not take water - dehydration - then died. This man knows it and he keep on takinh water more and more to avoid dehydration. But then died due to water intoxication.

Meaning here, arsenic is toxic, water also CAN BE toxic. The father of toxicology; Paracelsus said that "Everything is Toxic" What difference between toxic and remedy is the dose.


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